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Oxidative stress markers and C-reactive protein in pediatric patients on hemodialysis

Manal F Elshamaa1, Samar Sabry, Mohamed Nabih

  • 1Department of Pediatrics, National Research Center, Elbehoos Street, Dokki, Cairo, Egypt. manal_elshmaa@hotmail.com

Annals of Nutrition & Metabolism
|October 16, 2009
PubMed

Insights

Children on hemodialysis (HD) experience increased oxidative stress and inflammation, indicated by higher malondialdehyde (MDA) and high-sensitivity C-reactive protein (hsCRP) levels. These markers correlate with cardiovascular risks in pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Health
  • Oxidative Stress Research

Background:

  • Children with end-stage renal disease on hemodialysis (HD) face significant oxidative stress.
  • This imbalance impairs antioxidant defenses and elevates oxidative stress markers, contributing to inflammation.

Purpose of the Study:

  • To compare plasma total antioxidant capacity (TAC) and lipid peroxidation products (MDA) in pediatric HD patients versus healthy controls.
  • To investigate the relationship between these oxidative stress markers and high-sensitivity C-reactive protein (hsCRP) in pediatric HD patients.

Main Methods:

  • Plasma TAC, MDA, and hsCRP levels were measured in 30 pediatric HD patients and 20 healthy controls (HC).

Main Results:

  • Pediatric HD patients exhibited significantly higher TAC, MDA, and hsCRP levels compared to HC.
  • A positive correlation was observed between TAC and hsCRP, and MDA and hsCRP in HD patients.

Conclusions:

  • Children on HD show elevated oxidative stress, with MDA levels strongly linked to this susceptibility.
  • Increased hsCRP in HD patients signifies heightened inflammatory activity, potentially explaining cardiovascular complications.
Abstract

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