Related Experiment Video
Updated: Jun 19, 2026
Creation of Reversible Cholestatic Rat Model
Published on: May 21, 2011
A new technique for inducing and releasing obstructive jaundice in rats
17th Surgical Department, Ankara Numune Teaching and Research Hospital, Ankara, Turkey. mtoruc @ yahoo.com
Aim:
It was the aim of this study to develop a simple, effective and reversible model of obstructive jaundice in rats.
Material And Method:
Totally, 24 rats were divided into 3 groups: the sham group including sham-operated control rats who underwent laparotomy only (n = 8), the common bile duct standard ligation technique (CBD-SL) group including rats with CBD ligation using silk (n = 8), and the CBD new ligation technique (CBD-NL) group consisting of rats with CBD ligation by a new technique (n = 8). After release of the ligations, the CBD-SL group continued as the CBD-SL releasing group, and the CBD-NL group as the CBD-NL releasing group.
Results:
It was observed that all the CBD ligated rats were both clinically and biochemically jaundiced but they were relieved after reversing the procedure.
Conclusion:
We present a simple, effective and reliable rat model which is suitable for studies which require a reversal of obstructive jaundice in rats.
