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Related Concept Videos

Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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Related Experiment Video

Updated: Jun 19, 2026

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

Declining renal function after myocardial infarction predicts poorer long-term outcome.

C Aengus Murphy1, Stephen D Robb, Robin A P Weir

  • 1Department of Cardiology, Western Infirmary, Glasgow, Scotland, UK. aengus_murphy@hotmail.com

European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
|October 16, 2009
PubMed
Summary

Long-term decline in kidney function after myocardial infarction (MI) is linked to increased mortality. Monitoring renal function post-MI is crucial for predicting patient outcomes and guiding cardiovascular care.

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Myocardial Infarction and Functional Outcome Assessment in Pigs
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Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

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Last Updated: Jun 19, 2026

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

Area of Science:

  • Cardiology
  • Nephrology
  • Clinical Epidemiology

Background:

  • In-hospital renal function decline post-myocardial infarction (MI) predicts poor outcomes.
  • Long-term changes in kidney function after MI are less understood.
  • This study investigates chronic renal function changes and their prognostic value after MI.

Purpose of the Study:

  • To track long-term changes in renal function following myocardial infarction (MI).
  • To assess the correlation between chronic renal function changes and patient outcomes.
  • To identify risk factors for mortality after MI based on renal function trajectories.

Main Methods:

  • Utilized data from the MONICA register for individuals with a first MI.
  • Screened participants in 1995 and 1998 to assess estimated glomerular filtration rate (eGFR).
  • Tracked all-cause and cardiovascular mortality up to 2006.

Main Results:

  • Mean eGFR decline was -1.91 ml/min/1.73 m² over the study period.
  • A significant negative correlation was observed between eGFR decline and baseline eGFR.
  • The highest eGFR decline group showed increased adjusted hazard ratios for all-cause (1.86) and cardiovascular (2.06) mortality.
  • A creatinine rise >0.3 mg/dl correlated with significantly higher mortality risks.

Conclusions:

  • Chronic changes in renal function after MI are a significant predictor of long-term prognosis.
  • Monitoring renal function post-MI is essential for risk stratification.
  • Interventions targeting renal health may improve outcomes for MI survivors.