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Diffuse neonatal hemangiomatosis treatment with cyclophosphamide: a case report
Aleksandar Vlahovic1, Radoje Simic, Dragomir Djokic
1Division of Pediatric surgery, Department of Plastic Surgery and Burns, Institute for Mother and Child Health Care of Serbia, New Belgrade, Serbia. aleksandarvlahovic@yahoo.com
Journal of Pediatric Hematology/Oncology
|October 16, 2009
Summary
Diffuse neonatal hemangiomatosis in an infant was treated with cyclophosphamide after corticosteroids failed. This treatment successfully resolved liver hemangiomas and heart failure, leading to full recovery.
Area of Science:
- Pediatric Oncology
- Dermatology
- Vascular Anomalies
Background:
- Diffuse neonatal hemangiomatosis is a rare condition characterized by numerous hemangiomas.
- Early diagnosis and management are crucial for preventing severe complications.
Observation:
- A 3-month-old male infant presented with 63 cutaneous hemangiomas, as well as visceral involvement in the liver, kidneys, and tracheobronchial tree.
- The infant exhibited symptoms of heart failure, necessitating immediate medical intervention.
Findings:
- Initial treatment with corticosteroids showed limited efficacy.
- Cyclophosphamide, administered in a specific dosage regimen, led to significant regression of liver hemangiomas and resolution of cardiac failure.
- Follow-up imaging confirmed the marked decrease in liver hemangioma size.
Implications:
- Cyclophosphamide is an effective therapeutic option for severe diffuse neonatal hemangiomatosis unresponsive to corticosteroids.
- Successful treatment can lead to complete recovery and prevent long-term sequelae.
- This case highlights the importance of multidisciplinary management for complex vascular anomalies.
