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Updated: Jun 19, 2026

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
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Tissue engineering in urology.

Derek J Matoka1, Earl Y Cheng

  • 1Department of Pediatric Urology, Children's Memorial Hospital and the Feinberg School of Medicine, Northwestern University, Chicago, IL.

Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada
|October 16, 2009
PubMed
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Tissue engineering creates biological substitutes to restore tissue function. While promising, widespread clinical application requires further innovation in scaffold design, cell sourcing, and blood vessel growth (angiogenesis).

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Biotechnology

Background:

  • Tissue engineering aims to develop functional biological substitutes for damaged tissues.
  • Current research focuses on creating implantable grafts with in vivo functions mirroring healthy tissue.

Purpose of the Study:

  • Review the fundamental technologies for generating tissue-engineered grafts in vitro.
  • Examine current trends in scaffold design, angiogenesis promotion, and cell source optimization.
  • Describe existing therapeutic applications of tissue-engineered constructs.

Main Methods:

  • Review of existing literature and technologies in tissue engineering.
  • Analysis of trends in scaffold construction, angiogenesis, and cell sourcing.
  • Description of current therapeutic modalities utilizing tissue-engineered constructs.

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Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
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Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

Published on: February 24, 2016

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Last Updated: Jun 19, 2026

Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
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Published on: July 5, 2024

Tissue Engineering of a Human 3D in vitro Tumor Test System
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Tissue Engineering of a Human 3D in vitro Tumor Test System

Published on: August 6, 2013

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
09:43

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

Published on: February 24, 2016

Main Results:

  • Established technologies enable in vitro generation of grafts with potential for in vivo function.
  • Key trends include tailored scaffold construction, promoting blood vessel growth, and identifying optimal cell sources.
  • Several therapeutic applications are currently in use.

Conclusions:

  • Significant progress has been made in tissue engineering.
  • Widespread clinical applicability remains a future goal.
  • Continued innovation is expected to unlock the field's full potential.