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Related Experiment Video

Updated: Jun 19, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Sero-negative celiac disease with dermatitis herpetiformes: a case report.

Mehreen Adhi1, Asma Farooq, Syed Ali Hamid

  • 1Department of Surgery, The Aga Khan University Hospital (Stadium Road), Karachi (74800), Pakistan. mehreen_adhi@yahoo.com

Cases Journal
|October 16, 2009
PubMed
Summary

Sero-negative celiac disease can occur, even with normal antibody tests. Intestinal biopsy is crucial for diagnosis when clinical suspicion for celiac disease is high.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Clinical Medicine

Background:

  • Celiac disease diagnosis typically relies on serological markers.
  • Negative serology can sometimes complicate diagnosis, necessitating further investigation.

Observation:

  • A 20-year-old female presented with chronic gastrointestinal and dermatological symptoms suggestive of malabsorption.
  • Standard celiac disease serological tests (anti-tissue transglutaminase, anti-endomysial antibodies) and skin biopsy were negative.
  • Intestinal biopsy revealed subtotal villous atrophy, confirming celiac disease.

Findings:

  • The patient exhibited subtotal villous atrophy on intestinal biopsy despite negative celiac disease serological markers.
  • A gluten-free diet led to significant symptom improvement, supporting the diagnosis.

Related Experiment Videos

Last Updated: Jun 19, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Implications:

  • This case highlights that serological testing alone may not be sufficient for diagnosing celiac disease.
  • Intestinal biopsy remains a critical diagnostic tool, especially in cases with strong clinical suspicion and negative serology.
  • Clinicians should consider intestinal biopsy to rule out celiac disease when serological results are inconclusive but symptoms persist.