Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Imprinting01:22

Imprinting

Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
Evolutionary Psychology01:20

Evolutionary Psychology

Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the human psyche...
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adapting the Serious Illness Conversation communication training workshop from the Western to an Asian context in Singapore.

BMC medical education·2026
Same author

Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring.

Aging·2025
Same author

Perinatal nutrition as a key regulator of genomic imprinting: a new paradigm for maternal-child health.

Frontiers in nutrition·2025
Same author

Environmental epigenomics and the human imprintome.

Environmental epigenetics·2025
Same author

Epigenetics, human imprintome, and chronic diseases.

Essays in biochemistry·2025
Same author

DNA methylation of imprint control regions associated with Alzheimer's disease in non-Hispanic Blacks and non-Hispanic Whites.

Clinical epigenetics·2024
Same journal

Neuroinflammation in glaucoma: a myriad of cellular pathways and players.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Correction: THBS1: a biomarker for PCOS and its role in pathogenesis via the PI3K/AKT signaling pathway.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Elucidating the therapeutic targets and multi-target mechanisms of salvianolic acid A for diabetic nephropathy.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

DeepDisSNP: Predicting disease-associated SNPs by representation learning on disease and SNP linkage disequilibrium networks.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

A comprehensive full-length transcriptome atlas across multiple organs of an Indian yak breed-Arunachali.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Detection of a complex chromosomal rearrangement in a novel mouse mutant by optical genome mapping.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
See all related articles

Related Experiment Video

Updated: Jun 19, 2026

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

Imprinting evolution and human health.

Radhika Das1, Daniel D Hampton, Randy L Jirtle

  • 1Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|October 16, 2009
PubMed
Summary
This summary is machine-generated.

Genomic imprinting, a unique gene control, leads to parent-specific gene expression. This process is vital in mammalian evolution and implicated in human diseases like cancer and neurological disorders.

More Related Videos

Single Oocyte Bisulfite Mutagenesis
13:18

Single Oocyte Bisulfite Mutagenesis

Published on: June 27, 2012

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
12:09

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

Related Experiment Videos

Last Updated: Jun 19, 2026

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

Single Oocyte Bisulfite Mutagenesis
13:18

Single Oocyte Bisulfite Mutagenesis

Published on: June 27, 2012

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
12:09

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

Area of Science:

  • Genetics
  • Evolutionary Biology
  • Epigenetics

Background:

  • Genomic imprinting causes parent-of-origin-dependent, monoallelic gene expression.
  • This functional haploid state has significant evolutionary and health implications.
  • Epigenetic mechanisms control the allele-specific silencing of imprinted genes.

Purpose of the Study:

  • To review the evolution of genomic imprinting in Therian mammals.
  • To discuss the role of imprinted genes in human health and disease.
  • To explore theories behind the evolution of imprinting.

Main Methods:

  • Literature review of genomic imprinting.
  • Analysis of evolutionary theories of imprinting.
  • Discussion of imprinting's role in mammalian speciation and human diseases.

Main Results:

  • Genomic imprinting is crucial for mammalian evolution and speciation.
  • Imprinted genes are linked to the pathogenesis of human cancers and neurological disorders.
  • Various theories attempt to explain the evolutionary drivers of imprinting.

Conclusions:

  • Genomic imprinting is a fundamental epigenetic process with profound evolutionary and medical significance.
  • Understanding imprinting's evolution provides insights into its role in human health and disease.