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Updated: Jun 19, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
[Interleukin-1 cytokines, inflammasomes, NOD-signalosomes and autoinflammation]
1Division of Infection, Inflammation & Immunity, Southampton General Hospital, School of Medicine, University of Southampton, Southampton, UK. s.gadola@soton.ac.uk
Abstract:
The understanding of the genetic and immunological basis of human periodic fever syndromes, in particular cryopyrin-associated periodic syndromes (CAPS), has led to important new insights into the pathogenesis of monogenic and complex interleukin-1beta-associated autoinflammatory diseases. Currently the focus of attention is on the nucleotide-binding oligomerization domain (NOD)-like receptors (NLR), which take part in the regulation of the synthesis and maturation of cytokines in the IL-1 families, NOD-signalosomes and inflammasomes.
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