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Related Experiment Video

Updated: Jun 19, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Lung adenocarcinomas with micropapillary components.

Ryo Maeda1, Noritaka Isowa, Hideyuki Onuma

  • 1Division of Thoracic Surgery, Matsue Red Cross Hospital, Matsue, Shimane, Japan. ryomaedamatsue@yahoo.co.jp

General Thoracic and Cardiovascular Surgery
|October 16, 2009
PubMed
Summary
This summary is machine-generated.

Micropapillary adenocarcinoma in lung cancer indicates aggressive behavior, often leading to lymph node metastasis and pleural invasion. Closer monitoring and surgical evaluation are recommended for patients with this histological subtype.

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Last Updated: Jun 19, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Area of Science:

  • Oncology
  • Pathology

Background:

  • Micropapillary adenocarcinoma is an increasingly recognized histological subtype.
  • It holds prognostic importance across various carcinomas.

Purpose of the Study:

  • To present clinicopathological findings of lung adenocarcinomas with micropapillary components.
  • To evaluate the clinical significance of micropapillary features in lung adenocarcinoma.

Main Methods:

  • Retrospective analysis of 15 patients with micropapillary components (April 2005 - December 2008).
  • Evaluation of clinical presentation, lymph node metastasis, pleural invasion, pathological stage, and outcomes.
  • Surgical procedures included lobectomy or bilobectomy with lymph node dissection.

Main Results:

  • 8 out of 12 patients undergoing surgery showed lymph node metastases.
  • 14 out of 15 cases exhibited lymphovascular invasion.
  • 10 cases were up-staged due to lymph node metastases or pleural invasion.
  • Follow-up ranged from 1 to 42 months (median 16 months).
  • 7 patients were alive without disease, 7 alive with disease, and 1 died of disease.

Conclusions:

  • Micropapillary components signify aggressive behavior in lung adenocarcinoma.
  • Frequent lymph node metastases and pleural invasion are associated with this subtype.
  • Recommendations include careful search for metastases and closer patient follow-up.