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Related Experiment Video

Updated: Jun 19, 2026

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

Lymphoma in 3 related Rottweilers from a single household.

¹Bryanston Veterinary Hospital, PO Box 67092, Bryanston 2021, South Africa. rlobetti@mweb.co.za

Journal of the South African Veterinary Association

|October 17, 2009

Summary

Two sibling Rottweilers and their mother developed lymphoma, responding initially to chemotherapy but relapsing. Genetic predisposition is suspected due to the close relation and lack of environmental triggers in this canine cancer study.

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Published on: April 3, 2011

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Last Updated: Jun 19, 2026

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

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Published on: December 27, 2024

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Derivation of Thymic Lymphoma T-cell Lines from Atm^-/- and p53^-/- Mice

Published on: April 3, 2011

Area of Science:

Veterinary Oncology
Canine Genetics
Animal Disease Studies

Background:

Lymphoma is a common cancer in dogs.
Genetic factors can influence cancer development in animals.
Rottweilers may have a predisposition to certain cancers.

Observation:

Two sibling Rottweilers and their dam in the same household developed lymphoma.
The dogs presented with Stage IV and Stage III lymphoma, respectively.
All three dogs relapsed approximately 3 months after initial doxorubicin chemotherapy response.

Findings:

A familial clustering of lymphoma was observed in three related dogs.
No clear environmental trigger for the lymphoma cases was identified.
The rapid relapse suggests aggressive disease or treatment resistance.

Implications:

This case suggests a potential genetic predisposition to lymphoma in this dog breed.
Further research into canine lymphoma genetics is warranted.
Understanding genetic risk factors can aid in early detection and prevention strategies for canine cancers.