Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dose-dependent decrease in rat plasma amino acids after acute administration of ethanol.

M Hagman1, T Eriksson

  • 1Department of Clinical Chemistry, Sahlgren's Hospital, University of Gothenburg, Sweden.

The Journal of Pharmacy and Pharmacology
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The state of the art in beyond 5G distributed massive multiple-input multiple-output communication system solutions.

Open research Europe·2023
Same author

Influence of operational conditions and wastewater properties on the removal of organic micropollutants through ozonation.

Journal of environmental management·2021
Same author

Nighttime pasture access: Comparing the effect of production pasture and exercise paddock on milk production and cow behavior in an automatic milking system.

Journal of dairy science·2019
Same author

Is dissolved COD a suitable design parameter for ozone oxidation of organic micropollutants in wastewater?

The Science of the total environment·2018
Same author

The effects of high-sugar ryegrass/red clover silage diets on intake, production, digestibility, and N utilization in dairy cows, as measured in vivo and predicted by the NorFor model.

Journal of dairy science·2017
Same author

Effect of lifelong football training on the expression of muscle molecular markers involved in healthy longevity.

European journal of applied physiology·2017

Ethanol administration to male rats caused a dose-dependent reduction in plasma amino acid levels. This suggests both ethanol metabolism and the compound itself impact amino acid concentrations.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Toxicology

Background:

  • Ethanol consumption can alter physiological processes.
  • Previous research suggested ethanol oxidation is key to its effect on amino acids.

Purpose of the Study:

  • To investigate the dose-dependent effects of ethanol on plasma amino acid concentrations in male rats.
  • To elucidate the roles of ethanol oxidation and ethanol itself in these changes.

Main Methods:

  • Male rats received intraperitoneal injections of three different ethanol doses (0.66, 1.33, 2.00 g/kg).
  • Plasma amino acid levels were measured and compared to a saline-treated control group.
  • Ethanol oxidation enzyme saturation was considered based on the lowest dose administered.

Related Experiment Videos

Main Results:

  • A significant, dose-dependent decrease in most plasma amino acid concentrations was observed.
  • Total plasma amino acid concentration decreased by 5%, 16%, and 22% at the respective doses.
  • The effect was more pronounced at higher ethanol doses, even when oxidation pathways were saturated.

Conclusions:

  • Ethanol administration significantly reduces plasma amino acid levels in a dose-dependent manner.
  • Both the oxidation of ethanol and ethanol itself contribute to the observed decrease in plasma amino acids.
  • These findings highlight the complex biochemical impact of ethanol on amino acid homeostasis.