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Dhori virus induced lesions in mice
A R Filipe1, M C Peleteiro, H R de Andrade
1Center for Zoonoses Research, National Institute of Health, Aguas de Moura.
Acta Virologica
|December 1, 1990
Summary
Dhori virus and Thogoto virus are the only known tick-borne orthomyxoviruses. Both viruses show high liver tropism in mice, with similar organ damage to influenza virus infections.
Area of Science:
- Virology
- Zoonotic Diseases
- Arthropod-borne Viruses
Background:
- Dhori virus and Thogoto virus are the sole identified tick-borne members of the Orthomyxoviridae family.
- These viruses represent a unique group within the Orthomyxoviridae, distinct from typical influenza viruses.
Purpose of the Study:
- To characterize the pathogenic properties of Dhori virus in laboratory mice.
- To compare the disease manifestations of Dhori virus infection with those of Thogoto virus and influenza virus.
Main Methods:
- Infection of laboratory mice with Dhori virus.
- Histopathological examination of various organs to assess tissue damage.
- Comparative analysis of clinical signs and lesions.
Main Results:
- Dhori virus demonstrated significant hepatotropism, targeting the liver in laboratory mice.
- Lesions observed in multiple organs of infected mice were comparable to those caused by influenza virus.
- The pathogenicity profile of Dhori virus in mice resembles that of Thogoto virus.
Conclusions:
- Dhori virus shares key pathogenic characteristics, including hepatotropism and lesion similarities, with Thogoto virus.
- Tick-borne orthomyxoviruses like Dhori virus may present distinct disease patterns compared to airborne influenza viruses.
- Further research into tick-borne orthomyxoviruses is warranted to understand their zoonotic potential and epidemiology.