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Molecular genetic aspects of glial tumour evolution
C D James1, T Mikkelsen, W K Cavenee
1Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202.
Cancer Surveys
|January 1, 1990
Abstract:
Cancer can be viewed as a dynamic process driven by the cellular accumulation of genetic alterations that provide selective growth advantage. Such alterations can be classified as one of two fundamental types: acquired (cancer-affective, dominant) or eliminated (cancer suppressive, recessive). This review considers genetic alterations that occur during the development of the most common type of central nervous system tumour, glioma.