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Updated: Jun 19, 2026

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model

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Enteric coating derived from marine sponge collagen.

Martina Nicklas¹, Wolfgang Schatton, Sascha Heinemann

¹KliniPharm GmbH, Frankfurt, Germany.

Drug Development and Industrial Pharmacy

|October 17, 2009

Summary

A novel enteric coating derived from marine sponge collagen provides gastroresistance for oral medications. This sustainable coating meets regulatory standards for both pharmaceuticals and dietary supplements.

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Area of Science:

Pharmaceutical Technology
Biomaterials Science
Marine Biotechnology

Background:

Enteric coatings are crucial for oral drug delivery, protecting acid-labile or stomach-irritating compounds.
They ensure targeted drug release in the small intestine, enhancing therapeutic efficacy.
Current coatings often rely on synthetic polymers, prompting a search for natural alternatives.

Purpose of the Study:

To develop a novel gastroresistant delayed-release tablet coating using collagen from the marine sponge Chondrosia reniformis.
To assess the technical feasibility and performance of this marine-derived coating material.

Main Methods:

An aqueous coating dispersion was formulated using freeze-dried sponge collagen (15% w/w) as the film-forming agent.
Disintegration tests were performed according to European Pharmacopoeia (Ph. Eur.) standards at varying coating thicknesses.
Reproducibility, physical properties, and long-term stability of the coated tablets were evaluated.

Main Results:

A coating level of 13 mg/cm² demonstrated resistance to 0.1 M hydrochloric acid for over 2 hours.
Tablets disintegrated within 10 minutes in a phosphate buffer solution (pH 6.8), meeting Ph. Eur. requirements.
The coating process was reproducible, yielding tablets with satisfactory mechanical properties and stability for at least 6 months.

Conclusions:

The marine sponge collagen coating (12.9 mg/cm²) successfully meets Ph. Eur. standards for gastroresistant tablets.
This innovative biomaterial offers a viable, natural alternative for enteric coating applications.
The coating material also satisfies regulatory criteria for use in dietary supplements.