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Variable number of tandem repeats in zygosity diagnosis in twins
S Costanzi Porrini1, A Sciarra, N Sulli
1Chair of Medical Genetics, University of Rome La Sapienza, Italy.
Acta Geneticae Medicae Et Gemellologiae
|January 1, 1990
Abstract:
The use of DNA restriction fragment length polymorphisms (RFLP) to analyze variable number of tandem repeat (VNTR) sequences dispersed in the human genome, has become a powerful tool for the study of population genetics due to the very substantial polymorphism involved. Because the markers usually employed for twin zygosity determination (such as sex combination, placentation, HLA typing, blood group antigens, etc) may not be uniformly informative, we propose the use of synthetic olygonucleotides, representing VNTR "core" sequences, for the determination of zygosity in twins.