Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Acute Coronary Syndrome IV: Interprofessional Care

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improving medicines use in people with polypharmacy in primary care: a synopsis from the IMPPP cluster-RCT with pilot-feasibility study.

Health and social care delivery research·2026

Same author

Developing "De-stress pain," an intervention to reduce chronic pain-related distress: Proof of concept and qualitative assessment of acceptability.

British journal of pain·2026

Same author

Impact of interventions to prevent anxiety and depression in people with inflammatory rheumatological conditions: a systematic review.

Rheumatology advances in practice·2026

Same author

Attention-deficit hyperactivity disorder in children and young persons during the COVID-19 pandemic. A temporal trends analysis of electronic heath records in Greater Manchester, England.

JCPP advances·2026

Same author

Moving on from patient safety incidents: a qualitative study exploring GP perspectives in England.

The British journal of general practice : the journal of the Royal College of General Practitioners·2026

Same author

Primary Care Cardiovascular Risk Reduction after Pregnancy Complications: A Qualitative Systematic Review.

The British journal of general practice : the journal of the Royal College of General Practitioners·2026

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

Collaborative Depression Trial (CADET): multi-centre randomised controlled trial of collaborative care for

David A Richards¹, Adwoa Hughes-Morley, Rachel A Hayes

¹Mood Disorders Centre, School of Psychology, University of Exeter, EX4 4QG, UK. d.a.richards@exeter.ac.uk

BMC Health Services Research

|October 17, 2009

Summary

This study evaluated collaborative care for depression in UK primary care. Results will inform the National Health Service (NHS) on improving depression treatment delivery and patient outcomes.

More Related Videos

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

Related Experiment Videos

Last Updated: Jun 19, 2026

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

Area of Science:

Mental Health Research
Primary Care Medicine
Clinical Trial Design

Background:

Collaborative care models for depression have shown promise in the US.
Adaptation and evaluation of collaborative care in UK primary care are needed.
This Phase III trial follows a Phase II RCT, adhering to the MRC Complex Intervention Framework.

Purpose of the Study:

To establish the effectiveness of collaborative care for depression in the UK primary care setting.
To determine if US-developed collaborative care models can yield similar benefits for UK patients.
To provide evidence for NHS implementation of improved depression care.

Main Methods:

A multi-centre, cluster-randomised controlled trial.
GP practices randomized to either usual care or collaborative care.
Collaborative care involves case managers, psychological treatment, and enhanced communication, with depression symptoms (PHQ-9) as the primary outcome.

Main Results:

Primary outcome: symptoms of depression assessed by PHQ-9.
Data collection and analysis are ongoing for this Phase III trial.
Previous Phase II trial results informed the design of this study.

Conclusions:

Demonstrating effectiveness will support NHS adoption of collaborative care for depression.
This intervention aims to improve the organization and delivery of depression care in primary care.
The goal is to provide an effective and patient-acceptable model for enhanced depression care.