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Related Experiment Video

Updated: Jun 19, 2026

A Method to Estimate Cadaveric Femur Cortical Strains During Fracture Testing Using Digital Image Correlation
09:34

A Method to Estimate Cadaveric Femur Cortical Strains During Fracture Testing Using Digital Image Correlation

Published on: September 14, 2017

Measuring metacarpal cortical bone by digital x-ray radiogrammetry: a step forward?

Piet P Geusens, Willem F Lems

    Arthritis Research & Therapy
    |October 17, 2009
    PubMed
    Summary

    Early rheumatoid arthritis patients experienced significant bone loss in their metacarpals over five years. Severe inflammation and auto-antibodies predicted greater bone density reduction, highlighting risks for bone damage.

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    Area of Science:

    • Rheumatology
    • Bone Metabolism
    • Radiology

    Background:

    • Investigated metacarpal cortical bone mineral density (BMD) changes in early rheumatoid arthritis (RA) using digital X-ray radiogrammetry.
    • Assessed BMD over 1, 2, and 5 years to quantify bone loss.
    • Identified predictors of bone loss within the RA cohort.

    Discussion:

    • Significant metacarpal BMD loss was observed, reaching -5.6% by year 5.
    • Elevated erythrocyte sedimentation rate (ESR) and anti-cyclic citrullinated peptide (anti-CCP) levels independently predicted bone loss.
    • Patients with severe inflammation and high auto-antibody production exhibited the most substantial bone loss.

    Key Insights:

    • Early RA is associated with progressive metacarpal bone loss.
    • Inflammatory markers (ESR) and auto-antibodies (anti-CCP) are crucial indicators of bone loss risk.

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    Last Updated: Jun 19, 2026

    A Method to Estimate Cadaveric Femur Cortical Strains During Fracture Testing Using Digital Image Correlation
    09:34

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    Published on: September 14, 2017

    Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
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    Published on: January 31, 2025

  • Bone loss is more pronounced in RA patients with higher systemic inflammation and autoimmunity.

    • Outlook:

    • Further research is needed to elucidate the spatiotemporal relationship between joint erosions and juxta-articular/metacarpal bone loss in RA.
    • Understanding these relationships may refine risk stratification and therapeutic strategies for RA-associated bone damage.
    • Longitudinal studies correlating BMD changes with imaging of erosions are warranted.