Related Experiment Video
Updated: Jun 19, 2026
06:26
Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
Published on: May 16, 2021
[The discovery process in the pharmaceutical industry]
11 sente de Saint Clair, 91940 Gometz le Chatel, France. bscatton@club-internet.fr
Journal De La Societe De Biologie
|October 17, 2009
Summary
This review details pharmaceutical drug discovery, covering medicinal chemistry and biotherapeutics. It analyzes the research and development process, from target identification to candidate selection for new innovative drugs.
Area of Science:
- Pharmaceutical Sciences
- Medicinal Chemistry
- Biotherapeutics
Context:
- Overview of the global Research and Development (R&D) process in the pharmaceutical industry.
- Focus on the critical Discovery Research phase, preceding preclinical and clinical studies.
- Examination of both small molecule drug discovery and biologics development.
Purpose:
- To provide a detailed analysis of the drug discovery process.
- To elucidate the steps involved in generating drug candidates from medicinal chemistry and biotherapeutics.
- To highlight key stages from target validation to candidate proposal.
Summary:
- Medicinal chemistry: Discusses target selection, validation, high-throughput screening, hit-to-lead, and lead optimization for small molecules.
- Biotherapeutics: Details the generation and manufacturing of monoclonal antibodies and recombinant proteins.
- Integrates both approaches within the broader R&D framework.
Impact:
- Informs researchers and stakeholders about the complexities of modern drug discovery.
- Aims to streamline the identification and development of novel therapeutic agents.
- Contributes to understanding the pipeline for innovative pharmaceuticals.
Related Concept Videos
01:26Drug Discovery: Overview
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
01:11Clinical Trials: Overview
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
01:28Preclinical Development: Overview
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
01:26Drug Administration and Therapy Phases: Overview
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
01:19Pharmacovigilance
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
01:25Drug Regulation
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...