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Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly

Yvette I Sheline1, Marcus E Raichle, Abraham Z Snyder

  • 1Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA. yvette@npg.wustl.edu

Biological Psychiatry
|October 17, 2009
PubMed
Summary

Alzheimer's disease (AD) amyloid plaques disrupt brain connectivity even before cognitive decline. Resting-state fMRI detects these early changes in cognitively normal individuals with amyloid deposition.

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