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Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles
11:35

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Published on: December 9, 2022

Cellular quiescence: are controlling genes conserved?

Mitsuhiro Yanagida1

  • 1Okinawa Institute of Science and Technology Promotion Corporation (OISTPC), Initial Research Project (IRP), Uruma, Okinawa 904-2234, Japan. yanagida@kozo.lif.kyoto-u.ac.jp

Trends in Cell Biology
|October 17, 2009
PubMed
Summary

Cellular quiescence in fission yeast (Schizosaccharomyces pombe) involves ~1000 genes, including conserved superhousekeeping genes. This research aids understanding of aging and diseases like diabetes.

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Area of Science:

  • Cell Biology
  • Genetics
  • Molecular Biology

Background:

  • Cellular quiescence is a state of reversible growth arrest crucial for multicellular organisms.
  • The target of rapamycin complex (TORC) pathway regulates the transition between proliferation and quiescence.
  • TORC components Tti1 and Tel2 may govern phosphoinositide 3-kinase-related kinases.

Purpose of the Study:

  • To investigate the genetic requirements for cellular quiescence in Schizosaccharomyces pombe.
  • To identify genes involved in both proliferation and quiescence (superhousekeeping genes).
  • To explore the conservation of quiescence mechanisms across species.

Main Methods:

  • Utilized deletion mutants and temperature-sensitive mutants of Schizosaccharomyces pombe.
  • Conducted pilot studies to identify genes essential for quiescence.

Main Results:

  • Approximately 1000 genes were identified as necessary for quiescence.
  • Around 300 of these genes, termed superhousekeeping genes, also function during proliferation.
  • Findings suggest conservation of quiescence genes from yeast to humans.

Conclusions:

  • Schizosaccharomyces pombe is a valuable model for studying cellular quiescence.
  • Understanding quiescence mechanisms can provide insights into aging, diabetes, obesity, and neurodegeneration.
  • Conserved genes highlight fundamental biological processes.