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Relationship between platelet indices and aortic valve sclerosis

Murat Sucu1, Vedat Davutoglu, Ibrahim Sari

  • 1Department of CardiologyGaziantep University, Medical FacultyGaziantep, Turkey. sucu@gantep.edu.tr

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|October 17, 2009
PubMed

Insights

Aortic valve sclerosis (AVS) is linked to higher mean platelet volume (MPV) and platelet distribution width (PDW). Further research is needed to explore antithrombotic therapies for AVS patients.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Pathology

Background:

  • Aortic valve sclerosis (AVS) involves aortic valve thickening, similar to atherosclerotic coronary heart disease.
  • AVS is a progressive condition without significant valve narrowing.

Purpose of the Study:

  • To investigate the relationship between AVS and key platelet indices: mean platelet volume (MPV), platelet distribution width (PDW), and platelet count.
  • To compare platelet indices in patients with and without AVS.

Main Methods:

  • A study included 210 patients, with 150 diagnosed with AVS and 60 in the control group.
  • Echocardiography was used for evaluation, and MPV, PDW, and platelet counts were measured.
  • Patient groups were compared based on AVS presence, demographic data, and risk factors like hypertension, diabetes, and smoking.

Main Results:

  • Patients with AVS showed significantly higher MPV (9.56 ± 1.3 fL vs. 9.15 ± 1.0 fL, P = .022) and PDW (16.9 ± 2.3% vs. 14.9 ± 2.3%, P = .001).
  • No significant differences were observed in white blood cell or platelet counts between the groups.
  • The AVS group had a higher prevalence of hypertension, diabetes mellitus, and smoking.

Conclusions:

  • Platelet production indices, specifically MPV and PDW, are elevated in patients with AVS.
  • The intricate connection between increased platelet indices and AVS warrants further investigation.
  • The potential efficacy of antithrombotic therapies in managing AVS requires additional research.
Abstract

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