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Updated: Jun 19, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Effects of heat stress on mammalian reproduction
1Department of Animal Sciences, University of Florida, PO Box 110910, Gainesville, FL 32611-0910, USA. hansen@animal.ufl.edu
Abstract:
Heat stress can have large effects on most aspects of reproductive function in mammals. These include disruptions in spermatogenesis and oocyte development, oocyte maturation, early embryonic development, foetal and placental growth and lactation. These deleterious effects of heat stress are the result of either the hyperthermia associated with heat stress or the physiological adjustments made by the heat-stressed animal to regulate body temperature. Many effects of elevated temperature on gametes and the early embryo involve increased production of reactive oxygen species. Genetic adaptation to heat stress is possible both with respect to regulation of body temperature and cellular resistance to elevated temperature.
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