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Capecitabine-induced cerebellar toxicity in a patient with metastatic colorectal cancer
Ioannis Gounaris1, Athar Ahmad
1Department of Oncology, Box 193, Addenbrookes Hospital, Hills Road, Cambridge, CB2 0QQ, UK. ioannis.gounaris@addenbrookes.nhs.uk
Introduction:
Capecitabine is an oral fluoropyrimidine that was designed to allow selective activation in tumour tissues, thus reducing toxicity. The neurologic toxicity of 5-fluorouracil, the original fluoropyrimidine, including an ataxic cerebellar syndrome is well described. However, only a few case reports exist describing a similar syndrome associated with capecitabine administration.
Case Report:
We report a case of reversible cerebellar toxicity during chemotherapy with a combination of capecitabine and oxaliplatin.
Discussion:
Rare fluoropyrimide-related toxicities are increasingly being reported in association with capecitabine. Clinical vigilance is required to ensure appropriate investigation and treatment.
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