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Related Concept Videos

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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Related Experiment Video

Updated: Jun 19, 2026

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

Developmental trajectories in early hematopoiesis.

Cornelis Murre1

  • 1Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA. murre@biomail.ucsd.edu

Genes & Development
|October 17, 2009
PubMed
Summary
This summary is machine-generated.

Hematopoietic stem cell development into lymphocytes involves debated pathways. This study identifies novel intermediate stages in hematopoietic progenitor cell development.

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Last Updated: Jun 19, 2026

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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

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Area of Science:

  • Hematology
  • Developmental Biology
  • Stem Cell Research

Background:

  • Hematopoietic stem cells (HSCs) are multipotent and self-renewing.
  • The differentiation pathways of HSCs into various blood cell lineages, particularly lymphocytes, are complex and not fully understood.
  • Early hematopoiesis involves multiple lineage segregation branchpoints.

Discussion:

  • This research investigates the developmental trajectory of hematopoietic progenitor cells.
  • The study identifies previously unrecognized intermediate stages in cell lineage commitment.
  • Understanding these stages is crucial for deciphering the precise mechanisms of hematopoiesis.

Key Insights:

  • Novel intermediate stages in hematopoietic progenitor cell development have been identified.
  • These findings offer new insights into the sequential steps of lymphocyte differentiation.
  • The research clarifies debated aspects of early hematopoietic development.

Outlook:

  • Further research can explore the molecular regulators of these newly identified intermediate stages.
  • This work may pave the way for therapeutic strategies targeting hematopoietic disorders.
  • The findings contribute to a more comprehensive model of blood cell formation.