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Updated: Jun 19, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Smart MR imaging agents relevant to potential neurologic applications.

C S Bonnet¹, E Tóth

¹Centre National de la Recherche Scientifique, Centre de Biophysique Moléculaire, Orléans, France.

AJNR. American Journal of Neuroradiology

|October 17, 2009

Summary

Molecular imaging uses specialized probes for noninvasive disease detection. Chemistry advancements are crucial for developing novel agents for molecular MRI, particularly Gd(3+)-based and PARACEST probes.

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Area of Science:

Chemistry
Biomedical Engineering
Radiology

Background:

Molecular imaging visualizes molecular signatures of disease noninvasively.
Effective molecular imaging relies on specific imaging probes, highlighting the importance of chemistry.
Magnetic Resonance (MR) imaging has seen advances in molecular agent design, but many are not yet in vivo.

Purpose of the Study:

To review the role of chemistry in molecular MR imaging.
To highlight Gd(3+)-based and PARACEST agents for neurobiological applications.
To showcase responsive probes for detecting ions, pH, enzymes, and oxygenation.

Main Methods:

Review of chemical advancements in molecular imaging probes.
Focus on Gadolinium (Gd(3+))-based contrast agents.
Focus on Proportional Autonomous Relaxation Contrast-Enhanced Steady State (PARACEST) agents.

Main Results:

Gd(3+)-based and PARACEST agents show promise for molecular MR imaging.
Responsive probes can detect various biological parameters like metal ions, pH, and oxygenation.
Significant chemical development is needed for in vivo applications.

Conclusions:

Chemistry is pivotal for developing advanced molecular MR imaging probes.
Gd(3+)-based and PARACEST agents represent key classes for future neurobiological applications.
Further research is needed to translate these chemical innovations into clinical practice.