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Preliminary results on cystic fibrosis haplotypes from patients diagnosed in Odessa
L De Benedetti1, P Ronchetto, M Devoto
1Laboratorio di Genetica Molecolare, Istituto G. Gaslini, Genova, Italy.
Acta Universitatis Carolinae. Medica
|January 1, 1990
Abstract:
Two RFLP's closely linked to the CF gene (KM.19/PstI and XV-2c/TaqI) have been analysed in a sample of CF families in which one or more affected children had been diagnosed by the CF Centre of Odessa. The most frequent haplotype in CF chromosomes (2-1) is the same observed with higher frequency in other populations. If confirmed on a larger sample of CF patients from the USSR, this result might be indicative of heterogeneity of mutations present in the Soviet population.