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Updated: Jun 19, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Plasma cell leukemia maintaining complete remission by syngeneic stem cell transplantation combined with low-dose
Masahiro Abe1, Hisayuki Yokoyama, Yasuo Tohmiya
1Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai.
Abstract:
Plasma cell leukemia (PCL) is a rare variant of multiple myeloma, which is very aggressive and resistant to chemotherapy. We report a case of PCL successfully treated with syngeneic peripheral blood stem cell transplantation followed by low-dose thalidomide. As of March 2009, the patient has maintained CR for 39 months posttransplant. The clinical course of the present case suggests that autologous stem cell transplantation using a graft with reduced contamination of malignant cells followed by low-dose thalidomide maintenance therapy may improve the PCL treatment outcome.
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