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Sweet's syndrome: an update and review.
1Department of Dermatology, New Jersey Medical School, Newark, NJ, USA.
Summary
Sweet's syndrome, or acute neutrophilic dermatosis, is an uncommon skin condition that can signal serious underlying diseases like leukemia or lymphoma. Treatment often involves corticosteroids, but other therapies may also be effective.
Area of Science:
- Dermatology
- Oncology
- Immunology
Background:
- Sweet's syndrome, also known as acute neutrophilic dermatosis, is a rare disorder.
- It can be a critical indicator of underlying malignancies such as leukemia or lymphoma.
- The condition presents with sudden, painful, red nodules or plaques, often accompanied by fever and elevated white blood cell counts.
Purpose of the Study:
- To provide a comprehensive overview of Sweet's syndrome.
- To highlight its association with systemic diseases and malignancies.
- To discuss current understanding of its pathogenesis and treatment options.
Main Methods:
- Review of existing literature on Sweet's syndrome.
- Analysis of clinical presentations and diagnostic criteria.
- Evaluation of treatment strategies and their efficacy.
Main Results:
- Sweet's syndrome is characterized by a dense dermal infiltrate of neutrophils.
- Cytokines play a significant role in its hypersensitivity reaction.
- Remission can occur with treatment of underlying conditions or spontaneously.
Conclusions:
- Sweet's syndrome is a significant dermatologic finding requiring thorough investigation for associated systemic disorders.
- Systemic corticosteroids remain the primary treatment.
- Alternative therapies like potassium iodide and colchicine show promise.
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