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Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
[Variations of troponin T in chronic hemodialysis patients: study of 52 cases]
Insights
Elevated cardiac troponin T (cTnT) levels are common in hemodialysis patients, linked to heart dysfunction and inflammation. These findings highlight the need for careful cardiac monitoring in renal patients.
Area of Science:
- Cardiology
- Nephrology
- Biochemistry
Context:
- Patients with severe renal dysfunction often exhibit elevated serum cardiac troponin T (cTnT).
- The clinical significance of these elevated levels in hemodialysis patients requires further investigation.
Purpose:
- To determine the frequency of elevated cTnT in hemodialysis patients.
- To explore the relationship between cTnT levels and cardiac dysfunction or inflammation.
Summary:
- This study measured cTnT in 52 hemodialysis patients and 20 controls. Elevated cTnT levels were observed in a significant portion of hemodialysis patients post-dialysis.
- A positive correlation was found between cTnT levels and indicators of cardiac dysfunction, left ventricular dysfunction, and inflammation (CRP).
Impact:
- The findings suggest that elevated cTnT in hemodialysis patients is multifactorial, involving cardiac dysfunction and inflammatory processes.
- This research underscores the importance of considering cardiac health in the management of patients with end-stage renal disease undergoing hemodialysis.
Background:
Patients with severe renal dysfunction have unexplained elevated serum concentrations of cardiac troponin T.
Aim:
Study the frequency of elevated cTnT in hemodialysis patients and investigated whether cTnT is elevated.
Methods:
The patient population consisted of 52 patients on maintenance hemodialysis and 20 healthy subjects. cTnT was measured before and after hemodialysis by using immunoenzymatic method. cTnT were undetectable in 7 cases(< 0.01 ng/ml) and higher than normal range (up to 0.1 ng/ml) in 9 cases. 32 cases have a level of cTnT > 0.01 and < 0.1 ng/ml. In addition, TnTc levels are significantly associated with cardiac dysfunction (p < 0.05) and inflammation (p 0.01).
Results:
After hemodialysis sessions, TnTc was less than 0.01 ng/1 in 11 patients (21.2%), between 0.01 and 0.1 ng/ml in 32 subjects (61.5%) and greater than 0.1 ng/ml in 9 subjects (17.3%). In the control group, only 1 subject (5%) had a rate of TnTc between 0.01 and 0.1 ng/ml, whereas it was less than 0.01 ng/ml for all others. We aim a statistically significant positive correlation between the rate of TnTc and heart failure (p < 0.05) on the one hand and serum CRP (p < 0.01) on the other.
Conclusion:
The causes of elevated cTnT levels in hemodialysis patients was multiple: cardiac dysfunction, left ventricular dysfunction and inflammation.
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