Related Experiment Video
Updated: Jun 19, 2026
Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
Published on: May 27, 2020
The restless brain: attention-deficit hyperactivity disorder, resting-state functional connectivity, and intrasubject
F Xavier Castellanos1, Clare Kelly, Michael P Milham
1Neidich Professor of Child and Adolescent Psychiatry, Phyllis Green and Randolph Côwen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, New York, USA. francisco.castellanos@nyumc.org
Recent neuroimaging research offers new insights into attention-deficit hyperactivity disorder (ADHD). Advances in resting-state functional connectivity and intrasubject variability are improving our understanding of ADHD pathophysiology.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Attention-deficit hyperactivity disorder (ADHD) presents complex heterogeneity.
- Traditional conceptualizations struggle to fully capture ADHD's underlying mechanisms.
Purpose of the Study:
- To review recent neuroimaging and endophenotypic advances in understanding ADHD.
- To highlight novel approaches for modeling ADHD pathophysiology.
Main Methods:
- Selective literature review of recent publications.
- Focus on resting-state functional connectivity, intrasubject variability, and diffusion tensor imaging.
Main Results:
- Resting-state functional connectivity shows promise for ADHD research.
- These findings are likely to integrate with studies on intrasubject variability.
Conclusions:
- Endophenotypic fractionation aids in addressing ADHD heterogeneity.
- Models incorporating intrinsic brain activity and reward processing are advancing rapidly.
