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Related Concept Videos

Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
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Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
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Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

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Related Experiment Video

Updated: Jun 19, 2026

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
10:32

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice

Published on: March 23, 2014

[Leprosy: a rare imported disease].

M Gain1, H Ghnaya, F Lepeytre

  • 1Service de médecine interne, hôpital Saint-Antoine, Assistance publique-Hôpitaux de Paris, université Paris-VI, rue du Faubourg-Saint-Antoine, 75012 Paris cedex, France. muriellegain2000@yahoo.fr

La Revue De Medecine Interne
|October 20, 2009
PubMed
Summary
This summary is machine-generated.

Leprosy, though rare in Western countries, remains a global endemic disease. Physicians should recognize imported cases, like this one presenting with skin lesions and neuropathy, diagnosed via skin biopsy.

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DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)

Published on: July 15, 2011

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Last Updated: Jun 19, 2026

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
10:32

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice

Published on: March 23, 2014

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)
09:39

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)

Published on: July 15, 2011

Area of Science:

  • Medical Science
  • Infectious Diseases
  • Dermatology

Background:

  • Leprosy is a chronic infectious disease caused by Mycobacterium leprae.
  • While endemic globally, it is considered rare in occidental countries.
  • Physicians must maintain awareness for imported cases.

Observation:

  • A 41-year-old male patient from the French West Indies presented with symptoms.
  • The patient exhibited nonspecific, extensive skin lesions.
  • Peripheral neuropathy was also a presenting symptom.

Findings:

  • Skin biopsy was performed for diagnostic examination.
  • The histopathological findings confirmed borderline lepromatous leprosy.
  • This case highlights a specific clinical presentation of leprosy.

Implications:

  • Reinforces the need for diagnostic awareness of leprosy in non-endemic regions.
  • Emphasizes the importance of skin biopsy in diagnosing unusual dermatological conditions.
  • Contributes to understanding the clinical spectrum of leprosy in imported cases.