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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

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Related Experiment Video

Updated: Jun 19, 2026

Quantification of Self-renewal in Murine Mammosphere Cultures
07:40

Quantification of Self-renewal in Murine Mammosphere Cultures

Published on: November 26, 2019

Myc's other life: stem cells and beyond.

Elisa Laurenti1, Anne Wilson, Andreas Trumpp

  • 1Ludwig Institute for Cancer Research Ltd, Lausanne Branch, University of Lausanne, Switzerland.

Current Opinion in Cell Biology
|October 20, 2009
PubMed
Summary

The Myc oncoprotein influences cell growth, differentiation, and stem cell properties by altering chromatin and regulating gene expression. Post-translational modifications further complicate Myc

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Last Updated: Jun 19, 2026

Quantification of Self-renewal in Murine Mammosphere Cultures
07:40

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Published on: November 26, 2019

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
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Published on: January 2, 2016

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo
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Published on: February 15, 2021

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The Myc oncoprotein has pleiotropic effects, impacting cell proliferation, differentiation, and metabolism.
  • In vivo studies confirm Myc's roles in stem cell properties, potentially via chromatin modification.
  • Myc regulates protein-coding and noncoding RNAs, including rRNAs, tRNAs, and miRNAs.

Purpose of the Study:

  • To review the multifaceted roles of the Myc oncoprotein.
  • To elucidate Myc's impact on cellular processes and stem cell biology.
  • To discuss Myc's regulatory mechanisms, including chromatin modification and post-translational modifications.

Main Methods:

  • Review of genetic and biochemical studies.
  • Analysis of cell line and in vivo experimental data.
  • Examination of Myc's transcriptional and post-translational regulation.

Main Results:

  • Myc regulates fundamental cellular processes like proliferation and differentiation.
  • Myc is crucial for the acquisition and maintenance of stem cell properties.
  • Myc modulates the global chromatin landscape and regulates diverse RNA species.
  • Post-translational modifications add complexity to Myc regulation in normal and malignant stem cells.

Conclusions:

  • Myc is a key regulator of cell growth, differentiation, and stemness.
  • Myc's functions are mediated through global chromatin remodeling and extensive gene regulation.
  • Dysregulation of Myc, influenced by post-translational modifications, is implicated in cancer stem cells.