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Master Transcription Regulators

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

Master Transcription Regulators

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

Transcription

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...

Transcription

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...

General Transcription Factors

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

Transcription Factors

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

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Related Experiment Video

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Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry

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Published on: May 17, 2016

Transcriptional networks controlling skeletal development.

Christine Hartmann¹

¹Research Institute of Molecular Pathology, 1030 Vienna, Austria. hartmann@imp.ac.at

Current Opinion in Genetics & Development

|October 20, 2009

Summary

Skeletal development depends on chondrocyte and osteoblast differentiation from mesenchymal precursors. This review covers key transcription factors controlling their function for proper skeletal formation.

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Area of Science:

Skeletal biology
Cell differentiation
Developmental biology

Background:

Vertebrate skeletal element formation requires differentiation of chondrocytes and osteoblasts from a common mesenchymal precursor.
Coordinated maturation of chondrocytes and osteoblasts is crucial for skeletal growth and development.
Numerous transcription factors have been identified that regulate chondrocyte and osteoblast function.

Purpose of the Study:

To review the roles of transcription factors in skeletal development.
To explore the mechanisms controlling transcription factor activity in chondrocytes and osteoblasts.

Main Methods:

Review of in vivo studies.
Analysis of in vitro studies.
Synthesis of current knowledge on transcription factor function.

Main Results:

Identified transcription factors active in chondrocytes, osteoblasts, or both.
Detailed their specific modes of action in skeletal development.
Summarized regulatory mechanisms controlling their activity.

Conclusions:

Transcription factors are critical regulators of skeletal formation.
Understanding these factors and their control is key to skeletal development research.