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Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza Infection
Published on: September 19, 2025
[Influenza A H1N1 respiratory infection in an intensive care unit in Argentina]
G Caprotta1, P González Crotti, Y Primucci
1Unidad de Cuidados Intensivos Pediátricos, Hospital de Trauma y Emergencia Dr Federico Abete, Malvinas Argentinas, Buenos Aires, Argentina. gcapro@gmail.com
Insights
During the 2009 Influenza A H1N1 pandemic, critical pediatric cases showed severe respiratory distress requiring mechanical ventilation. This study highlights a 50% mortality rate in pediatric intensive care unit admissions for H1N1.
Area of Science:
- Pediatric critical care medicine
- Infectious disease epidemiology
- Virology
Context:
- The 2009 Influenza A H1N1 pandemic presented with aggressive manifestations in children.
- Some pediatric cases necessitated intensive care unit admission.
- Understanding the clinical behavior of critical pediatric H1N1 cases is crucial.
Purpose:
- To describe the initial presentation and clinical behavior of critical pediatric patients with Influenza A H1N1.
- To analyze the outcomes of pediatric patients admitted to a Pediatric Intensive Care Unit (PICU) during the pandemic.
Summary:
- An observational, descriptive, and retrospective study was conducted in a 20-bed PICU.
- Twenty out of 113 tested patients (17.7%) were confirmed positive for Influenza A H1N1.
- Ninety-five percent of these pediatric patients required mechanical ventilation, with 90% experiencing respiratory distress.
Impact:
- The study identified severe respiratory disease requiring mechanical ventilation in confirmed pediatric H1N1 cases.
- A significant mortality rate of 50% was observed in the studied pediatric population.
- Findings underscore the severity of H1N1 in critically ill children and inform intensive care management strategies.
Introduction:
During the Influenza A H1N1 pandemic an aggressive manifestation of the disease was observed in children and some cases required admittance to intensive care unit. We describe the initial presentation and clinical behavior of critical pediatric patients treated in our unit.
Material And Methods:
Observational, descriptive and retrospective study performed in a 20 bed Pediatric Intensive Care Unit (PICU). All patients with H1N1 presence confirmed by Polymerase Chain Reaction (PCR) admitted from June 1st 2009 to August 1st 2009 were included.
Results:
Influenza A HINI virus was positive in 20 out of 113 patients (17,7%) tested , with 95% (19) of these patients requiring mechanical ventilation. Out of these 20, 18 (90%) had respiratory distress, 16 of them (80%) at admittance and 2 (10%) during their stay in PICU. The mortality rate was 50%.
Conclusion:
We observed severe respiratory disease that required mechanical ventilation in confirmed cases admitted to the PICU and a mortality rate of 50%.
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