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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
[Acute renal failure in Burkina Faso]
A Lengani1, D Kargougou, G B Fogazzi
1Service de néphrologie et hémodialyse, centre hospitalier universitaire Yalgado Ouédraogo, Ouagadougou 01, Burkina Faso. alengani2002@yahoo.fr
Nephrologie & Therapeutique
|October 20, 2009
Summary
Acute renal failure (ARF) is a significant concern in Burkina Faso, with limited access to dialysis. Medical causes, volume depletion, and infections are common, leading to high mortality despite dialysis indications.
Area of Science:
- Nephrology
- Public Health
- Epidemiology
Context:
- Uremic syndrome poses a significant health challenge in sub-Saharan Africa.
- Nephrology services are recently established in Burkina Faso, with a lack of epidemiological data on acute renal failure (ARF).
- This study addresses the critical need for understanding ARF in a resource-limited setting.
Purpose:
- To describe the clinical profile of hospitalized patients with acute renal failure in Burkina Faso.
- To identify the causes, comorbidities, and outcomes of ARF in this population.
- To highlight the challenges in managing ARF, particularly regarding renal replacement therapy.
Summary:
- A study of 121 hospitalized patients with ARF (creatinine > 240 µmol/L) in Burkina Faso revealed a mean age of 38.6 years.
- Medical causes (91 cases) predominated, with volume depletion, infections, and obstruction as key pathophysiological factors.
- Comorbidities included heart failure and severe hypertension; dialysis was indicated for 84 patients but only performed for 14, resulting in a 24% mortality rate.
Impact:
- The findings underscore the substantial burden of ARF in Burkina Faso and the challenges posed by limited access to essential treatments like dialysis.
- This research provides crucial epidemiological data to inform public health strategies and improve ARF management in sub-Saharan Africa.
- The study highlights the urgent need for enhanced nephrology infrastructure and resources to address preventable deaths from ARF.
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