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Related Concept Videos

Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...

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PRDC regulates placode neurogenesis in chick by modulating BMP signalling.

Nadja N Kriebitz1, Clemens Kiecker, Laura McCormick

  • 1MRC Centre for Developmental Neurobiology, 4th Floor New Hunts House, Kings College London, Guy's Campus, London SE1 1UL, UK.

Developmental Biology
|October 20, 2009
PubMed
Summary

Bone morphogenetic proteins (BMPs) maintain neurogenesis in epibranchial placodes. Protein Related to Dan and Cerberus (PRDC) antagonizes BMPs, regulating neuron development and positioning.

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Area of Science:

  • Developmental biology
  • Neuroscience

Background:

  • Epibranchial placodes form cranial sensory ganglia neurons.
  • Bone morphogenetic proteins (BMPs) are implicated in this process.
  • The precise role and regulation of BMP signaling in later placodal development remain unclear.

Purpose of the Study:

  • To investigate the role of BMP signaling in maintaining epibranchial placode neurogenesis.
  • To identify regulators of BMP signaling in this context.
  • To elucidate how BMP signaling is modulated during cranial sensory ganglia development.

Main Methods:

  • Gene expression analysis (Bmp4, Bmp7, PRDC).
  • Gain- and loss-of-function experiments for PRDC.
  • Analysis of neurogenesis in epibranchial placodes.

Main Results:

  • BMPs maintain placodal neurogenesis.
  • Protein Related to Dan and Cerberus (PRDC) acts as a BMP antagonist.
  • PRDC modulates BMP signaling, affecting Bmp4 expression.
  • Altered PRDC levels lead to inhibition or expansion of neurogenesis.

Conclusions:

  • BMP signaling is crucial for maintaining epibranchial placode neurogenesis.
  • PRDC is a key regulator of BMP activity in this system.
  • PRDC's modulation of BMPs is essential for correct neuron number and positioning.