Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.

Leishmaniasis

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

Fungal Phylum Microsporidia

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Weekly adalimumab: A promising approach for managing refractory non-infectious chronic pediatric uveitis.

Journal francais d'ophtalmologie·2025

Same author

Retraction Note: Bartonella henselae is usually not viable in lymph nodes of patients with cat scratch disease.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2025

Same author

Serum angiotensin-converting enzyme has low diagnostic value for pediatric sarcoid uveitis.

Journal francais d'ophtalmologie·2024

Same author

Retraction notice to "Tropheryma whipplei associated with diarrhoea in young children" [Clin Microbiol Infection 22 (10) (2016) 869-874].

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2024

Same author

Differences and similarities between Monkeypox and Chickenpox in children during an outbreak.

Travel medicine and infectious disease·2024

Same author

Children with poor access to healthcare in emergencies: standpoint and practices of pediatricians in France.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2022

Search research articles

Related Experiment Videos

[Pediatric Mediterranean spotted fever].

J-M Garnier¹, A-L Jurquet, K Retornaz

¹Service de Pédiatrie, CHU Nord, chemin des Bourrelly, 13015 Marseillle. jean-marc.garnier@ap-hm.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|October 20, 2009

Summary

Mediterranean spotted fever, caused by Rickettsia conorii transmitted by the brown dog tick, is prevalent in Southeastern France. Early diagnosis and treatment with doxycycline are crucial for good outcomes, especially in children.

Related Experiment Videos

Area of Science:

Infectious Diseases
Epidemiology
Dermatology

Context:

Mediterranean spotted fever (MSF) is primarily diagnosed in Southeastern France.
The brown dog tick (Rhipicephalus sanguineus) serves as both the vector and reservoir for Rickettsia conorii.

Purpose:

To outline the epidemiological characteristics, clinical presentation, and management of MSF in France.
To highlight diagnostic criteria and treatment options for MSF.

Summary:

MSF diagnosis in France involves fever, rash, and an inoculation scar during summer.
Pathological findings include diffuse vasculitis; delayed diagnosis can increase severity.
Pediatric prognosis is generally favorable with prompt treatment.

Impact:

Emphasizes the importance of timely diagnosis for improving patient outcomes in MSF cases.
Provides guidance on appropriate antibiotic therapy, including doxycycline and macrolides for pediatric patients under eight.