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Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual

Larry R McLean1, Ying Zhang, Hua Li

  • 1Discovery Research, sanofi-aventis, Bridgewater, NJ 08807, USA. Larry.Mclean@sanofi-aventis.com

Bioorganic & Medicinal Chemistry Letters
|October 20, 2009
PubMed

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Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.