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Dose response and efficacy of spinal manipulation for chronic cervicogenic headache: a pilot randomized controlled
Mitchell Haas1, Adele Spegman, David Peterson
1Center for Outcomes Studies, Western States Chiropractic College, 2900 NE 132nd Ave., Portland, OR 97230, USA. mhaas@wschiro.edu
Background Context:
Systematic reviews of randomized controlled trials suggest that spinal manipulative therapy (SMT) is efficacious for care of cervicogenic headache (CGH). The effect of SMT dose on outcomes has not been studied.
Purpose:
To compare the efficacy of two doses of SMT and two doses of light massage (LM) for CGH.
Patient Sample:
Eighty patients with chronic CGH.
Main Outcome Measures:
Modified Von Korff pain and disability scales for CGH and neck pain (minimum clinically important difference=10 on 100-point scale), number of headaches in the last 4 weeks, and medication use. Data were collected every 4 weeks for 24 weeks. The primary outcome was the CGH pain scale.
Methods:
Participants were randomized to either 8 or 16 treatment sessions with either SMT or a minimal LM control. Patients were treated once or twice per week for 8 weeks. Adjusted mean differences (AMD) between groups were computed using generalized estimating equations for the longitudinal outcomes over all follow-up time points (profile) and using regression modeling for individual time points with baseline characteristics as covariates and with imputed missing data.
Results:
For the CGH pain scale, comparisons of 8 and 16 treatment sessions yielded small dose effects: |AMD|
Conclusions:
Clinically important differences between SMT and a control intervention were observed favoring SMT. Dose effects tended to be small.
