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Related Concept Videos

Spinal Cord: Gross Anatomy01:15

Spinal Cord: Gross Anatomy

The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
Vertebral Column: Regions and Curvature01:16

Vertebral Column: Regions and Curvature

The vertebral column or spine is a flexible column that supports the head, neck, and body and  allows for their movements. It also protects the spinal cord.
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form the...
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
The Spinal Cord01:54

The Spinal Cord

The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats
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Published on: March 24, 2020

Split cervical spinal cord malformation and vertebral dysgenesis.

C Andro1, R Pecquery, P De Vries

  • 1Pediatric Orthopaedic Surgical Unit, Morvan Hospital, 5 Avenue Foch, 29609 Brest Cedex, France. christopheandro@hotmail.com

Orthopaedics & Traumatology, Surgery & Research : OTSR
|October 20, 2009
PubMed
Summary

This report details a rare case of type II split cord malformation in an 11-year-old boy, diagnosed prenatally. Close monitoring is crucial, with surgery reserved for neurological decline.

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A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury
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Published on: January 5, 2015

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09:24

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Published on: January 5, 2015

Area of Science:

  • Neurology
  • Developmental Biology
  • Medical Imaging

Background:

  • Split cord malformation (SCM) is a rare congenital anomaly of the spinal cord.
  • Type II SCM involves a non-bony septum dividing the cord.
  • Cervicothoracic SCM is exceptionally rare, making this case noteworthy.

Observation:

  • An 11-year-old male presented with a diagnosed type II split cord malformation at the cervicothoracic level.
  • The diagnosis was established prenatally via ultrasound and magnetic resonance imaging (MRI).
  • The patient was asymptomatic and had not undergone surgical intervention.

Findings:

  • The case highlights a rare presentation of vertebral malformation with diplomyelia, consistent with type II split cord malformation.
  • Prenatal diagnosis through advanced imaging (ultrasound, MRI) enabled early identification.
  • The cervicothoracic location of the malformation is an unusual feature.

Implications:

  • This case underscores the importance of prenatal screening for spinal cord anomalies.
  • Understanding embryological theories is key to explaining SCM pathogenesis.
  • Long-term clinical surveillance is essential, with surgical intervention reserved for cases of neurological deterioration.