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Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
Published on: July 13, 2019
BK virus nephropathy: a pediatric nephrologist's perspective
1Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. lhymes@emory.edu
Transplantation Reviews (Orlando, Fla.)
|October 20, 2009
Summary
Polyomavirus (BK)-associated nephropathy (BKVN) is a growing concern in pediatric kidney transplants, potentially causing graft failure. This review examines key studies on BKVN incidence, treatments, and risk factors in children.
Area of Science:
- Nephrology
- Pediatric Transplant Medicine
- Virology
Background:
- Polyomavirus (BK)-associated nephropathy (BKVN) is a significant complication in renal transplantation.
- While initially studied in adults, BKVN is increasingly recognized in pediatric recipients, potentially leading to allograft dysfunction.
- Early pediatric BKVN data were mainly case reports, but recent studies offer more comprehensive insights.
Purpose of the Study:
- To review and analyze significant studies focusing on BKVN in pediatric renal transplant recipients.
- To provide insights into the incidence, treatment efficacy, and risk factors of BKVN in children.
Main Methods:
- Literature review of retrospective and prospective studies on pediatric BKVN.
- Analysis of data concerning BKVN incidence, treatment outcomes, and associated risk factors in pediatric populations.
Main Results:
- Increasing number of publications on pediatric BKVN allows for focused analysis.
- Studies provide insights into BKVN incidence, treatment strategies, and risk factors in pediatric transplant patients.
Conclusions:
- BKVN is a critical issue in pediatric renal transplants, impacting allograft survival.
- Analysis of recent studies enhances understanding of BKVN management and prevention in children.
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