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Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

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Related Experiment Video

Updated: Jun 19, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
12:06

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Stem cells and liver repair.

Janet W C Kung1, Stuart J Forbes

  • 1MRC Centre for Regenerative Medicine, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom.

Current Opinion in Biotechnology
|October 20, 2009
PubMed
Summary
This summary is machine-generated.

Liver regeneration can fail in chronic disease, necessitating transplantation. Current research explores using stem cell-derived liver cells to restore liver mass and function, with early clinical trials showing promise.

More Related Videos

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination
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Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination

Published on: February 18, 2017

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells
07:37

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells

Published on: June 11, 2019

Related Experiment Videos

Last Updated: Jun 19, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
12:06

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination
08:52

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination

Published on: February 18, 2017

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells
07:37

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells

Published on: June 11, 2019

Area of Science:

  • Hepatology and Regenerative Medicine
  • Stem Cell Biology
  • Liver Disease Research

Background:

  • The liver possesses significant regenerative capacity via hepatocyte division and progenitor cell proliferation.
  • Chronic liver disease often impairs this regeneration, making liver transplantation the sole curative option.
  • Current therapeutic strategies focus on restoring liver mass and function.

Purpose of the Study:

  • To investigate the potential of stem cell-derived hepatocyte-like cells for liver repair and regeneration.
  • To explore methods for stimulating endogenous liver repair mechanisms.
  • To assess the applicability of these cells in drug testing and bio-artificial liver devices.

Main Methods:

  • Differentiation of human embryonic stem cells (ESCs) and adult somatic cells into hepatocyte-like cells.
  • Evaluation of stem cell progeny in animal models of liver disease.
  • Advancement of tissue culture techniques for improved cell functionality.

Main Results:

  • Stem cell differentiation yields hepatocyte-like cells with potential therapeutic applications.
  • Animal models show encouraging results for stem cell-based liver repair.
  • Clinical trials are being initiated based on promising preclinical data.

Conclusions:

  • Stem cell-derived hepatocyte-like cells offer a promising alternative to liver transplantation.
  • Further research into human liver development and improved tissue culture is essential.
  • The use of stem cells in liver disease holds significant therapeutic potential, progressing towards clinical application.