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Related Concept Videos

Yeast Signaling01:28

Yeast Signaling

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Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
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Inhibition of Cdk Activity02:34

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
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M cyclin...
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Positive Regulator Molecules02:39

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Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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Positive Regulator Molecules01:45

Positive Regulator Molecules

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To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
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Cells Coordinate Growth and Proliferation

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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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Related Experiment Video

Updated: Jan 18, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

484

CDKs and the yeast-hyphal decision.

Yue Wang1

  • 1Genes and Development Division, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore. mcbwangy@imcb.a-star.edu.sg

Current Opinion in Microbiology
|October 20, 2009
PubMed
Summary

Cyclin-dependent kinases (CDKs) regulate fungal cell shape. New research links CDKs to polarity proteins, revealing conserved mechanisms for yeast-hyphal transitions and fungal development.

Area of Science:

  • Cell Biology
  • Mycology
  • Molecular Biology

Background:

  • Fungal cells exhibit diverse morphologies, including dimorphism in species like Candida albicans, switching between yeast and hyphal forms.
  • Cyclin-dependent kinases (CDKs) are implicated in regulating the yeast-hyphal transition, but direct links to polarity machinery components were unclear.

Purpose of the Study:

  • To review recent findings establishing concrete links between CDKs and key polarity proteins.
  • To discuss conserved and specific mechanisms governing polarized growth in Candida albicans and Saccharomyces cerevisiae.

Main Methods:

  • Review of recent scientific literature.
  • Focus on findings detailing CDK interactions with polarity machinery components.

Main Results:

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Determination of the Mating Efficiency of Haploids in Saccharomyces cerevisiae

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Related Experiment Videos

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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
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Determination of the Mating Efficiency of Haploids in Saccharomyces cerevisiae

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  • Inhibitory phosphorylation of Cdc42 GTPase-activating proteins (GAPs) is a common mechanism for polarized growth.
  • The hyphal-specific cyclin Hgc1 in C. albicans, with CDK Cdc28, phosphorylates Rga2, septins, and Efg1, promoting hyphal development.

Conclusions:

  • CDKs are directly linked to the polarity machinery, regulating fungal cell morphology.
  • Conserved and organism-specific mechanisms involving CDK-mediated phosphorylation control polarized growth in fungi.