Related Experiment Video

Updated: Jun 19, 2026

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

Serum levels of the adipokine chemerin in relation to renal function

Dörte Pfau1, Anette Bachmann, Ulrike Lössner

  • 1Department of Internal Medicine III, University of Leipzig, Leipzig, Germany.

Diabetes Care
|October 20, 2009
PubMed

Insights

Serum chemerin levels are significantly elevated in patients undergoing chronic hemodialysis (CD) compared to controls. Glomerular filtration rate (GFR) independently predicts these higher chemerin levels in both groups.

Area of Science:

  • Nephrology
  • Endocrinology
  • Biochemistry

Background:

  • Chemerin is an adipokine implicated in metabolic and inflammatory processes.
  • Chronic kidney disease (CKD) is associated with altered levels of various adipokines.

Purpose of the Study:

  • To compare serum chemerin levels in patients on chronic hemodialysis (CD) with healthy controls.
  • To investigate the relationship between chemerin levels and renal function, glucose/lipid metabolism, and inflammation.

Main Methods:

  • Serum chemerin was quantified using ELISA in CD patients (n=60) and controls (n=60).
  • Correlations were analyzed with clinical and biochemical parameters, including glomerular filtration rate (GFR).

Main Results:

  • Serum chemerin levels were more than twofold higher in CD patients (542.2 microg/l) versus controls (254.3 microg/l) (P < 0.001).
  • GFR independently predicted circulating chemerin concentrations in both patient groups (P < 0.05 for controls, P < 0.01 for CD patients).

Conclusions:

  • Markers of renal function are independently associated with circulating chemerin levels.
  • Chemerin may play a role in the pathophysiology of chronic kidney disease and its complications.
Abstract

More Related Videos

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance (Clcr), a...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...