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Heart rate variability and heart rate recovery in patients with coronary artery ectasia
Yasin Turker1, Mehmet Ozaydin, Habil Yucel
1Gulkent State Hospital, Isparta Turkey.
Insights
Patients with coronary artery ectasia (CAE) exhibit reduced heart rate variability (HRV) and impaired heart rate recovery (HRR). These findings suggest autonomic dysfunction may play a role in CAE development and progression.
Area of Science:
- Cardiology
- Autonomic Nervous System Function
- Heart Rate Variability Analysis
Background:
- Coronary artery ectasia (CAE) is a dilatation of coronary arteries, a variant of coronary artery disease (CAD).
- Autonomic dysfunction, indicated by altered heart rate variability (HRV) and heart rate recovery (HRR), is linked to increased cardiovascular risk.
- No prior studies have investigated the relationship between HRV, HRR, and CAE.
Purpose of the Study:
- To investigate heart rate recovery (HRR) and heart rate variability (HRV) in patients with coronary artery ectasia (CAE).
Main Methods:
- The study included 50 patients with CAE and 35 healthy controls.
- Evaluated time-domain HRV parameters (e.g., SDNN, RMSSD, pNN50) and HRR during exercise stress tests.
- Utilized electrocardiography, echocardiography, Holter monitoring, and biochemical tests.
Main Results:
- Patients with CAE showed significantly lower HRV parameters, including standard deviations of all N-N intervals and averages of N-N intervals.
- Heart rate recovery (HRR) was significantly reduced in the CAE group compared to controls.
- The incidence of abnormal HRR was significantly higher in patients with CAE (44%) versus controls (14%).
Conclusions:
- Time-domain heart rate variability (HRV) parameters are reduced in patients with coronary artery ectasia (CAE).
- Heart rate recovery (HRR) is impaired in individuals with CAE, suggesting potential autonomic dysfunction.
Background:
Coronary artery ectasia (CAE) is characterized by an abnormal dilatation of the coronary arteries, which is a variant of coronary artery disease (CAD). Increased sympathetic activity or decreased vagal modulation of cardiac function assessed by heart rate variability (HRV) analysis has been associated with an increased risk of coronary artery disease and mortality and angiographic progression of coronary atherosclerosis, as well as arrhythmia and sudden cardiac death. Heart rate recovery index is a strong indicator of risk in asymptomatic and symptomatic CAD. To the best of our knowledge, no study has been conducted to investigate the relationship between HRV, heart rate recovery, and CAE. The purpose of this study was to examine the changes in heart rate recovery and HRV measurements in coronary artery ectasia.
Methods:
The study population consisted of 50 consecutive patients (24 women; mean age 46+/-5 years) with CAE, and 35 asymptomatic healthy individuals comprised the control group (19 women; mean age 44+/-7 years). We performed electrocardiography, echocardiography, Holter analysis, exercise stress test, routine biochemical tests and evaluated the clinical characteristics. Time-domain parameters of HRV (mean R-R intervals; standard deviations of all N-N intervals; standard deviations of the averages of N-N intervals), the root mean square of the difference in successive R-R intervals, proportion derived by dividing the number of interval differences of successive N-N intervals greater than 50 ms by the total number of N-N intervals (pNN50) were evaluated. Heart rate recovery was defined as the difference in the heart rate from peak exercise to 1 min after peak exercise.
Results:
Standard deviations of all N-N intervals (123.7+/-30.3 vs. 178.8+/-52.7, P<0.001), standard deviations of the averages of N-N intervals (95.2+/-27.1 vs. 120.2+/-39.6, P = 0.001), total number of N-N intervals (11.9+/-8.6 vs. 17.1+/-6.4, P = 0.004) were significantly lower in the CAE group than in healthy controls. The root mean square of the difference in successive R-R intervals was lower in CAE patients than controls, but the differences between groups were not statistically significant (47.5+/-23.1 vs. 56.2+/-23.6, P = 0.097). The heart rate recovery values measured during the recovery phase were significantly lower in the CAE group compared with the control group (21.3+/-11.1 vs. 29.3+/-11.9, P = 0.002). The incidence of abnormal heart rate recovery [22 (44%) vs. 5 (14%), P = 0.002] was greater in patients with CAE group than in controls.
Conclusion:
The results of this study showed that time-domain HRV parameters and heart rate recovery were reduced in patients with CAE.
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