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Related Experiment Video

Updated: Jun 19, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Endothelial dysfunction after drug eluting stent implantation.

M van den Heuvel1, O Sorop, H M M van Beusekom

  • 1Department of Cardiology, Cardiovascular Research School COEUR, Erasmus Medical Center, Rotterdam, The Netherlands.

Minerva Cardioangiologica
|October 20, 2009
PubMed
Summary

Coronary drug-eluting stents (DES) can impair endothelial function, affecting barrier integrity, inflammation, and vascular tone. These effects may extend distally, posing risks beyond the stented area.

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Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Interventional Cardiology

Background:

  • Endothelial dysfunction is a key factor in coronary artery disease (CAD) and adverse outcomes post-coronary drug-eluting stent (DES) implantation.
  • Understanding the impact of DES on endothelial function is crucial for improving patient outcomes.

Purpose of the Study:

  • To review current evidence on the effects of coronary DES on endothelial function.
  • To explore the mechanisms and clinical implications of DES-induced endothelial dysfunction.

Main Methods:

  • Comprehensive review of clinical and experimental studies.
  • Analysis of data on endothelial barrier function, adhesion, thrombosis, inflammation, and vascular tone.

Main Results:

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Published on: November 24, 2016

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Last Updated: Jun 19, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model
08:33

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

Published on: November 24, 2016

  • Both general stenting and DES appear to impair endothelial functions.
  • DES-induced endothelial dysfunction can affect vascular beds distal to the stent.
  • Mechanisms underlying DES-induced endothelial dysfunction are being elucidated.

Conclusions:

  • Coronary DES can negatively impact endothelial function in ways that extend beyond the local stented region.
  • Further research into clinical complications and potential solutions for DES-associated endothelial dysfunction is warranted.