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Updated: Jun 19, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Scanning fiber angle-resolved low coherence interferometry.

Yizheng Zhu¹, Neil G Terry, Adam Wax

¹Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.

|October 20, 2009

Summary

This summary is machine-generated.

We developed a fiber-optic probe for measuring scatterer size deep within samples. This technique uses angle-resolved low coherence interferometry to accurately determine particle sizes with subwavelength precision.

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Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

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Published on: October 2, 2021

Area of Science:

Biomedical Optics
Optical Metrology
Materials Science

Background:

Accurate determination of scatterer size is crucial in various scientific fields.
Existing methods may lack depth resolution or require sample destruction.
Need for non-invasive, depth-resolved scatterer sizing techniques.

Purpose of the Study:

To present a novel fiber-optic probe for Fourier-domain angle-resolved low coherence interferometry.
To enable depth-resolved determination of scatterer size.
To achieve subwavelength accuracy in sizing measurements.

Main Methods:

Utilized a scanning single-mode fiber to collect angular scattering distributions.
Employed Mie theory for analyzing scattering data to determine average scatterer size.
Integrated low coherence Mach-Zehnder interferometry for depth sectioning.
Designed a sample arm with a fixed fiber illuminator and a scanning collection fiber.

Main Results:

Successfully developed and characterized a fiber-optic probe for depth-resolved scatterer sizing.
Demonstrated subwavelength accuracy in determining scatterer sizes.
Validated the probe's performance using a double-layer phantom with known microsphere sizes.

Conclusions:

The developed fiber-optic probe is effective for depth-resolved scatterer size determination.
The system achieves high accuracy, enabling subwavelength sizing.
This technique holds promise for applications requiring precise microstructural analysis in scattering media.