Related Experiment Video
Updated: Jun 19, 2026
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
TIMI risk score for acute myocardial infarction according to prognostic stratification
Jaqueline Locks Pereira1, Thiago Mamôru Sakae, Michele Cardoso Machado
1Universidade do Sul de Santa Catarina, SC - Brasil. jaquelinelocks@yahoo.com.br
Insights
The Thrombolysis in Myocardial Infarction (TIMI) risk score effectively predicts mortality in acute myocardial infarction patients. Higher TIMI scores correlate with increased hospital mortality and reduced fibrinolytic use.
Area of Science:
- Cardiology
- Clinical Risk Stratification
- Acute Myocardial Infarction Management
Background:
- The Thrombolysis in Myocardial Infarction (TIMI) risk score was developed from clinical trials with fibrinolysis-eligible patients.
- Patient risk profiles in clinical trials may differ from unselected, real-world populations.
- Assessing the TIMI score's applicability in routine clinical practice is crucial.
Purpose of the Study:
- To evaluate the clinical management and outcomes of hospitalized acute myocardial infarction patients.
- To analyze patient evolution based on risk stratification using the TIMI score.
Main Methods:
- Retrospective analysis of 103 ST-segment elevation acute myocardial infarction cases.
- Patients admitted to Hospital Nossa Senhora da Conceição between 2004-2005 were categorized into three TIMI risk groups.
Main Results:
- Overall hospital mortality was 17.5%.
- Mortality rates were 0% (low-risk), 8.1% (medium-risk), and 55.6% (high-risk).
- High-risk patients faced a 14.1-fold increased risk of death and received fibrinolytic therapy 50% less often than low-risk patients.
Conclusions:
- A progressive increase in mortality and in-hospital complications was observed with higher TIMI risk scores.
- High-risk patients were less likely to receive thrombolytic treatment compared to low-risk patients.
- The TIMI score demonstrates significant prognostic value in unselected acute myocardial infarction populations.
Background:
The TIMI (Thrombolysis in Myocardial Infarction) risk score is derived from clinical trial involving patients who are eligible for fibrinolysis. As the risk profiles of these cases differ from those found in non-selected populations, it is important to review the applicability of the score in usual clinical conditions.
Objectives:
To evaluate the management and clinical evolution of hospital inpatients with acute myocardial infarction, according to risk stratification by the TIMI score.
Methods:
We evaluated, retrospectively, 103 cases of acute myocardial infarction with ST-segment elevation admitted to the Hospital Nossa Senhora da Conceição - Tubarão, in 2004 and 2005. The cases were analyzed in three risk groups according to the TIMI score.
Results:
The hospital mortality after infarction was 17.5%. In the low-risk group there was no death. The mortality was 8.1% in the medium risk group and 55.6% in the high-risk group. The risk of death in cases of high risk was 14.1 times higher than in the cases of medium and low risk (95% CI = 4.4 to 44.1 and p <0.001). The chance of receiving fibrinolytic was 50% lower in the high-risk group in relation to the low risk group (95% CI = 0.27 to 0.85, p = 0.004).
Conclusion:
There was a progressive increase in mortality and incidence of in-hospital complications according to the stratification by the TIMI score. High risk patients received thrombolytic less frequently than the patients at low risk.
Related Concept Videos
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:30Acute Coronary Syndrome I: Introduction
01:30Heart Failure IV: Classification and Diagnostic Evaluation
01:12Relative Risk
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations