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Updated: Jun 19, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Association between periodontal diseases and systemic diseases
Patrícia Weidlich1, Renata Cimões, Claudio Mendes Pannuti
1Department of Periodontology, Federal University of Rio Grande do Sul, Brazil.
Periodontal disease, an oral condition, may link to systemic issues like cardiovascular disease and diabetes. Research in Brazil shows associations, but more studies are needed to confirm a direct cause for these links.
Area of Science:
- Oral Health
- Systemic Health
- Epidemiology
Background:
- Growing evidence links periodontal disease to various systemic conditions.
- The Brazilian population's specific data on this association remains underexplored.
Purpose of the Study:
- To review existing literature on the association between periodontal disease and systemic diseases in Brazil.
- To identify research gaps concerning periodontal disease and its systemic links within the Brazilian context.
Main Methods:
- Systematic review of published studies.
- Focus on studies conducted in the Brazilian population.
- Inclusion criteria focused on cardiovascular diseases, adverse pregnancy outcomes, diabetes, and respiratory diseases.
Main Results:
- A limited number of studies (3 cardiovascular, 7 pregnancy, 9 diabetes, 1 pneumonia) were identified in Brazil.
- Most studies indicated a potential association between periodontitis and systemic conditions.
- Causal relationships between periodontal disease and systemic diseases were not definitively established.
Conclusions:
- While associations are suggested, a causal link between periodontal disease and systemic conditions in Brazil requires further investigation.
- Well-designed, larger-scale interventional studies are necessary for the Brazilian population.
- Future research should aim to elucidate the causal pathways and strengthen evidence in Brazil.
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