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Updated: Jun 19, 2026
11:50
Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
Published on: January 7, 2020
[Management of preterm labor]
Roberto Eduardo Bittar1, Marcelo Zugaib
1Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina, Universidade de São Paulo - USP - São Paulo, SP, Brasil. roberto.bittar@hcnet.usp.br
Summary
Uterolytics can prolong preterm labor, allowing for crucial treatments like glucocorticoids. Atosiban is a safer, though costly, option, while other agents have significant side effects.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
Context:
- Preterm delivery necessitates interventions to prolong gestation.
- Informed decisions require evaluating gestational age, maternal-fetal condition, and drug profiles.
Purpose:
- To review the efficacy and safety of uterolytic agents for preterm labor management.
- To guide clinical decisions on selecting appropriate tocolytic therapies.
Summary:
- Beta-adrenergic agonists, calcium channel blockers, and cytokine receptor antagonists can prolong gestation.
- Atosiban, a cytokine receptor antagonist, offers a safer profile but at a higher cost.
- Magnesium sulfate and cyclooxygenase inhibitors have limited efficacy and significant side effects.
- Evidence for nitric oxide donors is insufficient, and antibiotics are not indicated for preterm labor.
Impact:
- Provides a comparative overview of uterolytic agents for clinical practice.
- Highlights the importance of balancing efficacy, safety, and cost in tocolytic therapy selection.
- Informs evidence-based guidelines for managing preterm labor.
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